Trends in Cognitive Sciences
ReviewFrontal theta as a mechanism for cognitive control
Section snippets
Frontal computations are revealed by theta band activities
The prefrontal cortex allows us to transcend routines and habits to make better decisions. However, how does it actually ‘do’ this? As cognitive neuroscientists, we need to aim to move beyond descriptive findings and psychological correlates for a better understanding of how the brain underlies the mind. A mechanistic perspective is ideal for addressing how latent neural features underlie emergent psychological constructs.
Although the marriage of cognitive neuroscience and formal computational
Theta reflects active cortical functioning
Primate theta band (approximately 4–8 Hz) activities reflect a more discrete range of activities than the similarly named ‘theta’ observed in rat hippocampus (approximately 4–12 Hz). In primates, theta is broadly distributed across the brain [6] and appears to reflect active operations of the generative cortex, particularly during high-level cognitive processes, such as memory encoding and retrieval, working memory retention, novelty detection, and realizing the need for top-down control 7, 8, 9,
Frontal midline theta and the realization of the need for control
The realization of the need for control appears to be conveyed by frontal midline theta (FMθ) activities recorded from sensors overlying medial prefrontal cortex (mPFC). These FMθ activities have largely been quantified as event-related potential (ERP) components that reflect mPFC-related control processes elicited by novel information, conflicting stimulus–response requirements, punishing feedback, and the realization of errors. These potentials are known by varied and sometimes overlapping
Theta phase is a biologically plausible candidate for neuronal computation and communication
We propose that these theta-band similarities not only suggest that these phenomena are aspects of a common high-level process, but also may indicate how the need for control is biophysically realized and communicated. Time-varying changes in the phase angle reflect population-wide oscillations of neuronal membrane potentials [37]. This synchronization can create temporal windows for segregating cortical populations [38], which can separate information intake and transfer processes 39, 40.
Potential roles of theta in the instantiation of control
It is becoming increasingly clear that these FMθ activities reflect uncertainty in varied circumstances (Box 1). Given that the mPFC is sensitive to varied circumstances indicating a need for control [49], it should be expected that this system commonly reacts to novelty, conflict, punishment, and error, each of which indicate a need for enhanced control processes to change behavior adaptively. Thus, it is important to consider whether this theta signal acts to communicate specific information
What to do with a surprise signal?
Here, we describe some ways by which mPFC-generated surprise signals lead to task-specific adjustments in control (Figure 4). FMθ is sensitive to both unexpected uncertainty (volatility) and expected uncertainty (risk) [13], suggesting that it serves as both a teaching signal and an alarm of the need for control. This observation suggests that the information content of the signal, at least as measured on the human scalp, is minimal. Yet, even a simple signal of uncertainty can lead to a
Caveats for such a broad description
Any description of mPFC processes is bound to be complicated by the high base rate of activation in areas such as MCC across experimental demands [79]. It should be expected that some mPFC processes are not reflected by FMΘ, and that some FMΘ processes do not necessarily involve a phasic response to uncertainty. Moreover, other frequency bands have been shown to have a role in the implementation of control 19, 22, 74. It remains an important goal to specify the role of frontal theta in relation
Concluding remarks
Even a simple surprise signal can be used to communicate many different things. If the mPFC responds to unsigned prediction errors using a theta-band process capable of intersite entrainment, this would provide a plausible mechanism by which surprise could influence action selection, shift attention, cautiously adjust behavior, and enhance sensory precision. Most compellingly, such seemingly complex interactions may emerge simply by virtue of the connectivity and timing of biophysical processes
Acknowledgments
The authors thank Alex Shackman for his helpful discussions on these topics. This report was supported by NIH RO1 MH080066-01 and NSF 1125788.
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