Criteria used to assess study design according to the IDEAL framework7
| IDEAL stage | Identifying study characteristics |
| 1 (Idea) | Case report. |
| 2 a (Development) | Single-center/single intervention; case series/ prospective cohort. |
| 2b (Exploration) | Prospective multicenter exploration cohort study or pilot/feasibility multicenter RCTs. |
| 3 (Assessment) | Full-scale RCT which involves a comparison to routine clinical practice. |
| 4 (Long-term) | Long-term evaluation of the implementation within routine clinical practice using registries or databases. |
IDEAL, Idea, Development, Exploration, Assessment and Long-term fFollow-up; RCT, randomized controlled trial .