Table 2

Primary and secondary objectives of the MAST trial

Objectives	Outcome measures/endpoints
Primary objective	Assess the proportion of patients that had additional electrode contacts implanted in the SEEG-defined seizure onset zone.
Secondary objectives	For each case, we will assess: Pre-implantation confidence of the MDT members in identifying a seizure onset zone (prior to MELD information) as a measure of the ‘difficulty’ of the SEEG exploration Number of electrodes added Number of electrodes already in identified lesions Was a MELD-identified cluster part of the SOZ (and if so, how many clusters?) Would the SOZ have been identified without MELD? Blinded neurophysiological assessment of the SOZ contacts with and without additional electrodes Putative resection boundaries with and without the additional electrodes, to be modelled by a neurosurgeon Safety of adding additional electrodes

MDT, multidisciplinary team; MELD, multicentre epilepsy lesion detection; SEEG, stereoelectroencephalography; SOZ, Seizure Onset Zone.