Costs and drivers of counterfactual studies: The TVT CRN*
| Counterfactual studies | Total subjects | Total sites | Study duration (years) | Evaluations per year | Total procedure count | Total cost per study |
| A | 2000 | 39 | 5 | 1 | 5 | $ 21 949 424 |
| B | 550 | 27 | 5 | 1 | 5 | $ 7 539 932 |
| C | 1700 | 27 | 5 | 1 | 5 | $ 18 814 232 |
| D | 1000 | 28 | 5 | 1 | 5 | $ 11 911 048 |
| E | 200 | 28 | 5 | 1 | 5 | $ 4 165 448 |
| F | 1000 | 57 | 10 | 1 | 7 | $ 17 798 692 |
| G | 1000 | 29 | 5 | 1 | 5 | $ 11 925 264 |
| H | 1000 | 57 | 10 | 1 | 7 | $ 17 798 692 |
| I | 1000 | 45 | 5 | 1 | 5 | $ 12 152 720 |
| J | 200 | 37 | 5 | 1 | 5 | $ 4 293 392 |
| K | 100 | 41 | 5 | 1 | 5 | $ 3 382 056 |
| L | 1000 | 65 | 10 | 1 | 7 | $ 17 979 140 |
| M | 150 | 29 | 5 | 1 | 5 | $ 3 695 564 |
| N | 150 | 29 | 5 | 1 | 5 | $ 3 695 564 |
| O | 150 | 29 | 5 | 1 | 5 | $ 3 695 564 |
| P | 100 | 29 | 5 | 1 | 5 | $ 3 211 464 |
*Note. The calculations assume all patients are treated inside USA, requiring inperson evaluations, and the study was not randomized and had no control group. The letters designating the individual studies correspond with the studies listed in table 3.