Table 1

Costs and drivers of counterfactual studies: The TVT CRN*

 Counterfactual studies Total subjects Total sites Study duration (years) Evaluations per year Total procedure count Total cost per study A 2000 39 5 1 5 $21 949 424 B 550 27 5 1 5$ 7 539 932 C 1700 27 5 1 5 $18 814 232 D 1000 28 5 1 5$ 11 911 048 E 200 28 5 1 5 $4 165 448 F 1000 57 10 1 7$ 17 798 692 G 1000 29 5 1 5 $11 925 264 H 1000 57 10 1 7$ 17 798 692 I 1000 45 5 1 5 $12 152 720 J 200 37 5 1 5$ 4 293 392 K 100 41 5 1 5 $3 382 056 L 1000 65 10 1 7$ 17 979 140 M 150 29 5 1 5 $3 695 564 N 150 29 5 1 5$ 3 695 564 O 150 29 5 1 5 $3 695 564 P 100 29 5 1 5$ 3 211 464
• *Note. The calculations assume all patients are treated inside USA, requiring inperson evaluations, and the study was not randomized and had no control group. The letters designating the individual studies correspond with the studies listed in table 3.