Table 2

Incident rate ratios (IRR) of outcomes following index aortic valve replacement (AVR) procedure between patients implanted with BV or MV, overall and stratified by follow-up time, and adjusted for age, sex and Charlson Comorbidity Index Score group

≤5 years follow-up6–10 years follow-up0–10 years follow-up
Number of eventsIRR (95% CIs)Number of eventsIRR (95% CIs)Number of eventsIRR (95% CIs)
BVMVBVMVBVMV
18–64 years
Reoperation31460.77 (0.52 to 1.14)30115.48 (2.38 to 12.62)61571.88 (1.29 to 2.74)
Readmissions
 AMI18360.75 (0.41 to 1.38)10280.49 (0.26 to 0.94)28640.68 (0.43 to 1.09)
 Stroke22590.40 (0.27 to 0.60)16291.00 (0.50 to 2.04)38880.70 (0.50 to 0.98)
 hemorrhage331020.36 (0.26 to 0.50)18590.58 (0.32 to 1.05)511580.53 (0.41 to 0.69)
 Thromboembolism21370.68 (0.41 to 1.12)14231.14 (0.66 to 1.96)35601.01 (0.67 to 1.52)
Mortality (cardiovascular)70840.94 (0.72 to 1.23)23261.50 (0.99 to 2.27)931101.33 (1.12 to 1.59)
Mortality (all-cause)1251440.89 (0.70 to 1.11)55801.25 (0.93 to 1.69)1802241.29 (1.12 to 1.49)
65+ years
Reoperation55210.61 (0.37 to 1.01)1790.86 (0.45 to 1.65)72300.78 (0.53 to 1.17)
Readmissions
 AMI249700.71 (0.53 to 0.96)113370.95 (0.66 to 1.36)3621070.86 (0.67 to 1.10)
 Stroke347900.82 (0.64 to 1.06)132430.85 (0.60 to 1.21)4791330.90 (0.74 to 1.09)
 hemorrhage4711330.77 (0.62 to 0.95)163461.00 (0.69 to 1.44)6341790.92 (0.76 to 1.12)
 Thromboembolism249600.87 (0.65 to 1.17)82181.34 (0.84 to 2.14)331781.10 (0.91 to 1.33)
Mortality (cardiovascular)9192390.80 (0.69 to 0.92)2801050.69 (0.59 to 0.81)11993440.82 (0.72 to 0.95)
Mortality (all-cause)16704150.85 (0.74 to 0.97)7982520.85 (0.75 to 0.95)24686670.89 (0.82 to 0.97)
Total
Reoperation86670.65 (0.51 to 0.83)47202.75 (1.00 to 7.55)133871.25 (0.78 to 2.01)
Readmissions
 AMI2671060.77 (0.60 to 0.98)123650.93 (0.71 to 1.23)3901710.92 (0.74 to 1.14)
 Stroke3691490.75 (0.63 to 0.89)148720.98 (0.78 to 1.23)5172210.95 (0.83 to 1.08)
 hemorrhage5042350.66 (0.54 to 0.82)1811020.94 (0.73 to 1.20)6853370.86 (0.70 to 1.06)
 Thromboembolism270970.84 (0.69 to 1.01)96411.35 (1.05 to 1.72)3661381.15 (1.01 to 1.30)
Mortality (cardiovascular)9893230.90 (0.82 to 0.98)3031310.92 (0.73 to 1.16)12924541.04 (0.92 to 1.18)
Mortality (all-cause)17955590.90 (0.84 to 0.97)8533321.05 (0.94 to 1.18)26488911.10 (1.01 to 1.21)
  • NB: total follow-up time, patients were right censored at either death or end of follow-up, depending on which occurred first. Each cardiovascular event had separate follow-up times to include if the event, death or end of follow-up period occurred first.

  • AMI, acute myocardial infarction; BV, bioprosthetic valve; MV, mechanical valve.